duke wisconsin national championship controversial call refereesDuke won the national championship tonight. The Blue Devils defeated Wisconsin, 68-63, giving Mike Krzyzewski his fifth national title. Coach K’s team’s path to the title against the Badgers was partially secured by a questionable call by officials late in the second half. With 1:53 remaining in the game and Duke up, 63-58, Wisconsin’s Bronson Koenig missed a layup and attempted to get the ball back. Blue Devils’ forward Justise Winslow fought him for the ball and it went out of bounds. It was tough to tell who the ball went off during the live action. The officials originally ruled it was Duke’s ball and then went to the monitors. Watch Winslow’s finger bend backwards, an obvious sign that he touched the ball last. Apparently the refs didn’t have this angle, because Duke held possession after the replay. On the ensuing play, Blue Devils’ freshman guard Tyus Jones – the Final Four’s Most Outstanding Player – knocked down a 3-pointer to put his team up eight, essentially securing the win. This will be a tough one to get over, Badgers.
Gurugram: The Punjab and Haryana High Court on Tuesday concluded its hearing on whether Gurugram private metro is closed or handed over to the Haryana government for operations. The case that was heard by a bench of AK Tyagi and RK Jain has reserved its order and is likely to pronounce the judgment on Wednesday. According to sources the Delhi Metro Rail Corporation (DMRC) has expressed interest in running.Sources indicate that Infrastructure leasing and financial services (ILFS) that presently operates the private metro through its two subsidiaries of Rapid Metro Rail Gurugram Limited (RMRGL) north and south divisions softened its stance after DMRC proposal. Earlier citing heavy losses the private company had that it was unable to run operations as it could not sustain heavy losses each day it was incurring. “The management of Rapid Metro which was adamant on discontinuing its services from midnight changed its stance after lunch and accepted to operate it for some more time,” said Harinder Dhingra, a social activist who was present during the court hearing. Also Read – After eight years, businessman arrested for kidnap & murderThe mounting losses for Gurugram’s private metro have resulted in the pressure of the Haryana government to take over the Rapid Metro. However, it is not as easy as it seems with a huge debt of over Rs 3,000 crore already there is pressure on the government to take over 80 percent of the loan. If and when the Haryana government takes over the Rapid Metro it would mean they have to pay Rs 2,560 crore of loans. The financial troubles of IL&FS, the company that constructed the Rapid Metro, in mid-2018 and the Union government moving an application before the National Company Law Tribunal, Mumbai, seeking suspension of its board of directors on the grounds of massive mismanagement of public funds proved to be the last nail in the coffin of the RMGL. Also Read – Two brothers held for snatchingsThe RMRGL was among the 38 domestic group entities of IL&FS classified as “Red Entity” by the Union government, saying that it could not meet its payment obligations towards even senior secured financial creditors. For a city with an abysmal record on public transport, the news of Rapid Metro network struggling financially has come as a rude shock for the residents. Around 60,000 people commute daily in Rapid Metro, India’s first fully privately financed metro system that also acts as a feeder to the Delhi Metro Rail Corporation (DMRC) network, connecting at the Sikanderpur metro station on the Yellow Line.
TORONTO – A Toronto lawyer who conspired with his lover to kill his husband has been released on bail while he appeals his murder conviction.Demitry Papasotiriou-Lanteigne and his lover, Michael Ivezic, were convicted in June of first-degree murder in the killing of Allan Lanteigne. Both were sentenced to life in prison with no chance of parole for 25 years.Court documents show Papasotiriou-Lanteigne, 38, is seeking to appeal his conviction, alleging the jury’s verdict was unreasonable because it was based entirely on circumstantial evidence.The pair’s murder trial heard Papasotiriou-Lanteigne was in Greece, where he owns a home, when his husband was bludgeoned to death at their Toronto residence in March 2011.However, court heard Ivezic — with whom Papasotiriou-Lanteigne was having an affair — had returned to Toronto after visiting his lover in Greece and his DNA was found under Lanteigne’s fingernails.Prosecutors alleged Papasotiriou-Lanteigne arranged to have his husband arrive at the couple’s home at a certain time, while Ivezic waited to carry out the killing.Crown attorneys alleged money was the key motive, as it had been a source of strife for the couple and the two men had taken out a $2-million life insurance policy together a few years earlier, court documents show.Shortly after the murder, Papasotiriou-Lanteigne attempted to collect on the policy and on survivor benefits from his deceased husband’s employer, the documents show.Prosecutors alleged email exchanges between Papasotiriou-Lanteigne and his husband, and those between him and his lover, proved his involvement in the murder plot.They pointed to one email in particular, sent the day of the killing, in which Papasotiriou-Lanteigne insisted his husband be home by a certain time.In seeking to have his conviction overturned, Papasotiriou-Lanteigne alleges the trial judge misapprehended the email and that his correspondence with both men is open to interpretation.The court of appeal has granted him bail until his case is concluded, under the supervision of his mother, his step-father and his step-father’s mother, according to court documents.While on bail, Papasotiriou-Lanteigne is under strict house arrest and monitored through a GPS ankle bracelet that he pays for himself, the documents say.The appeal court said it considered Papasotiriou-Lanteigne’s compliance with his pre-trial bail conditions in agreeing to his release.“I accept that, standing alone, (Papasotiriou-Lanteigne)’s connections to Greece may give pause for concern,” Justice Gary T. Trotter wrote.“However, any lingering concerns about flight are answered by his history of bail compliance and the strict release plan that is proposed.”The judge also said there is no concern for public safety.
The study included patients from St. Jude, the COG and adult cancer cooperative studies.Patient samples of many of the B-ALL subtypes are available to the international scientific community through the St. Jude data portal PROPEL (Public Resource of Patient-derived and Expanded Leukemias). PROPEL makes patient-derived leukemia xenograft samples available free of charge to researchers with no obligation to collaborate. NUTM1 gene rearrangement with different partner genes that researchers believe may be vulnerable to treatment HLF gene rearrangement to multiple genes, including TCF4 as well as the previously recognized partner TCF3. Three subtypes that share patterns of gene expression similar to those of established B-ALL subtypes. The classification suggests that the new subtypes, ETV6-RUNX1-like, KMT2A-like and ZNF384-like, have risk profiles and prognoses similar to the established subtype for which they are named. Additional subtypes driven by sequence mutations, including IKZF1 N159Y. Previous work from St. Jude and the Children’s Oncology Group TARGET initiative have shown IKZF1 (Ikaros) mutations to be a marker of high risk B-ALL. Reviewed by Alina Shrourou, B.Sc. (Editor)Jan 14 2019Like cartographers completing a map, investigators have identified multiple new subtypes of the most common childhood cancer–research that will likely improve the diagnosis and treatment of high-risk patients. St. Jude Children’s Research Hospital scientists led the study, which appears as an advance online publication today in the journal Nature Genetics.Researchers used integrated genomic analysis, including RNA sequencing, to define the genomic landscape of B-cell acute lymphoblastic leukemia (B-ALL) in almost 2,000 children and adults. B-ALL is the most common form of ALL and the most common cancer in children. B-ALL remains the leading cause of pediatric cancer death.Investigators identified 23 subtypes of B-ALL, including eight new subtypes, with distinct genomic and clinical features as well as outcomes. Subtype prevalence often varies with age. More than 90 percent of B-ALL cases can now be categorized by subtype compared with 70 percent a few years ago.”B-ALL has remarkable molecular diversity, which we and others have used to refine classification and drive the development of precision medicines to improve B-ALL treatment and outcomes,” said corresponding author Charles Mullighan, MBBS, M.D., a member of the St. Jude Department of Pathology. “Part of precision medicine is an accurate molecular diagnosis, which this study provides to more patients.”A novel subtype-defining alterationAlterations of the transcription factor gene PAX5 defined two new subtypes, including PAX5 P80R, as the first lymphoblastic leukemia initiated by a point mutation. “While secondary mutations are necessary and often involve kinase signaling, we show this point mutation impairs development of B lymphoid cells and promotes development of B-ALL in mice,” Mullighan said.The other PAX5 subtype, PAX5-altered, was defined by diverse alterations in the gene, including sequence mutations or rearrangements with one of 24 other genes. Together the PAX5 subtypes accounted for almost 10 percent of the previously uncategorized cases of B-ALL.The new subtypes include a high-risk variety of B-ALL that occurs primarily in adults. It is defined by rearrangement of the transcription factors BCL2 with MYC or BCL6. “This subtype has a dismal diagnosis,” Mullighan said. “Recognition of this subtype-defining rearrangement may lead to alternative therapy for patients.” In contrast, a subtype defined by rearrangement of the gene DUX4 was associated with a good prognosis in adults, as had previously been observed in children.Tracking gene expressionThe study demonstrated the capability of RNA sequencing to identify multiple types of genomic alterations, highlighting the utility of this technique for leukemia diagnosis, particularly when whole-genome sequencing is not available. Examples in this study included chromosomal rearrangements resulting in fusion genes, gene-expression profiles and other alterations.Related StoriesChemistry researchers patent new method for making anti-leukemia compoundsUnderstanding maintenance of quiescent stem cells in chronic myelogenous leukemiaStudy identifies patterns of chronic lymphocytic leukemia growth”Through this study, two-thirds of the previous uncharacterized B-ALL patients could be classified into different subtypes with distinct genetic alteration profiles and clinical features,” said co-first author Zhaohui Gu, Ph.D., a postdoctoral fellow in the Mullighan laboratory. “That may substantially speed up the development of customized treatments for these patients.”We also established a robust B-ALL classification pipeline based mainly on RNA sequencing data that may be integrated into clinical diagnosis of ALL,” Gu said.”As a clinician, these data describing the diversity of subtypes of B-ALL will allow us to refine our prognostic abilities for individual patients, and ultimately, will lead to the development of new targeted therapies that will more effectively treat the leukemia with fewer side effects,” said co-author Mark Litzow, M.D., professor of medicine at the Mayo Clinic and chair of the Leukemia Committee, Eastern Cooperative Oncology Group and the American College of Radiology Imaging Network, which contributed to the study.Additional subtypes revealedThe other newly identified subtypes include: Source:https://www.stjude.org/
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2018 The Associated Press. All rights reserved. Superman may be the Man of Steel, but he’s no Death Dealer. This undated photo provided by Heritage Auctions, HA.com, shows a vintage 1938 Action Comics #1 in which Superman made his debut. The comic sold at auction in Chicago on Thursday, May 10, 2018, for $573,600. (Emily Clements/Heritage Auctions, HA.com via AP) Comic books featuring the debuts of Superman, the Joker and Catwoman fetched hundreds of thousands of dollars at a Chicago auction Thursday, but the star was undoubtedly a painting by science fiction and fantasy artist Frank Frazetta.Heritage Auctions says Frazetta’s “Death Dealer 6” painting sold for a whopping $1,792,500—a record for one of his paintings and three times the $600,000 it was expected to get.A 1938 Action Comics #1 in which Superman debuted sold for $573,600—not the $650,000 the auction house thought it might go for but still a nice payday for the collector who bought it for $50,000 15 years ago.A Batman comic book from 1940 in which both the Joker and Catwoman debuted sold for $227,050. First Superman comic book to go up and away at eBay This undated photo provided by Heritage Auctions, HA.com, shows a Death Dealer 6 Painting by famed science fiction and fantasy artist Frank Frazetta. The auction house was expecting it would go for $600,000 but on Thursday, May 10, 2018, in Chicago, it ended up going for more than anyone has ever paid for a Frazetta: $1,792,500. (Heritage Auctions, HA.com via AP) Citation: Death Dealer painting outshines Superman comic at auction (2018, May 10) retrieved 18 July 2019 from https://phys.org/news/2018-05-death-dealer-outshines-superman-comic.html Explore further
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Why are we checking Facebook, Instagram, Twitter, then Facebook again when we just wanted to check the weather? In this Sept. 16, 2017, file photo, a person uses a smart phone in Chicago. For many of us, a smartphone addiction is not so much a debilitating disease but a constant, nagging inconvenience we can’t seem to shake. But it’s not all our fault. From the constant notifications to the color schemes to the “likes,” followers and in-game rewards out phones and the apps on them were created so we’ll use them as much as possible. But there are ways to fight back. (AP Photo, File) Turns out, smartphone addiction is by design. Think of the constant stream of notifications, color schemes in apps and all the “likes,” followers and in-game trophies. Our phones and apps are designed to give us short-term, feel-good rewards, so we’ll use them longer—at the expense of reading, enjoying the moment or simply being bored.Some companies are relenting in response to concerns from customers and experts. Google’s next operating system , for instance, will come with a “wind down” mode; the screen will automatically fade to grey at a designated time before bed. Another feature will automatically put your phone in “do not disturb” mode if you flip it face down on a table.But most Android phones won’t get this system, Android P, until late this year or even next year, if at all. And it’s unclear if Apple plans similar features for the iPhone.So, for now, here’s how you can outsmart the smartphone yourself:LIMIT NOTIFICATIONSNotice those red dots on iPhones and Samsung phones showing how many unread messages, news items or app updates you have left to read? Of course, you have.”Red is a trigger color that instantly draws our attention,” notes The Center for Humane Technology , an organization that promotes a healthier, less dependent relationship to technology.Other Android phones running the most recent version, Oreo, have smaller dots. There are no numbers, and colors are more subtle, but the concept is the same: to lure you into opening the app. © 2018 The Associated Press. All rights reserved. DETOX REGULARLYIt can be as simple as going to the bathroom without your phone or turning it off during meal times or even every Saturday. Leaving your phone behind helps your brain reset.If you need a prompt on just why you should “detox,” try Moment, an app that automatically tracks how much you use your iPhone or iPad each day. It’s not perfect, as the timer runs anytime your screen is unlocked, even if you’ve stepped away. Still, the results will probably surprise you. For Android, there’s an app called QualityTime.SET A SCHEDULENir Eyal, author of “Hooked: How to Build Habit-Forming Products,” compares humans to lab mice in an experiment of random rewards. Mice, it turns out, respond “most voraciously to random rewards,” Eyal wrote in 2012 .Social media apps have perfected the art of random rewards. You don’t know when you’ll get a friend request, or a like, or even when you’ll see a new post from a friend. Cue endless check-ins and scrolling. In this Nov. 12, 2016, file photo, octagon-side models look at their cell phones between mixed martial arts bouts at UFC 205 at Madison Square Garden in New York. Our phones and apps are designed to give us short-term, feel-good rewards, so we’ll use them as much as possible, at the expense of reading, enjoying the moment or simply being bored. Due in part to a backlash from customers and experts, some companies are relenting, Google, for example, plans features such as a “wind down” mode in its next mobile operating system, P, which will start arriving on phones in the fall. (AP Photo/Julio Cortez, File) Citation: Digital Life: Cutting back on a constant smartphone habit (2018, May 23) retrieved 18 July 2019 from https://phys.org/news/2018-05-digital-life-constant-smartphone-habit.html In this March 24, 2017, file photo, a Samsung Galaxy S8 Plus mobile phone is docked in a DeX device during a preview, in New York. It can be as simple as going to the bathroom without your phone or as extensive as signing up for an off-the-grid yoga retreat: Leaving your phone behind helps your brain reset. (AP Photo/Richard Drew, File) Explore further At a glance: How new Google features tap digital smarts Set aside a specific time each day to check Facebook—or email, or instant messages. Then resist the urge until the next scheduled time.Along those lines, try deleting the Facebook app from your phone and check only from a computer. This could help reduce the temptation to check all day.TURN OFF AUTOPLAYBinge-watching might be fun sometimes, but it shouldn’t be standard behavior. Services like YouTube and Netflix often play the next video automatically. Turn that off in the settings. Otherwise, it’s easy to forget where time went in the middle of a “Stranger Things” binge.GET AN ALARM CLOCKThere was a time not too long ago when we were able to wake up without our phones, using a magical device called an alarm clock. Get one.The Center for Humane Technology suggests banishing phones from your bedside, if not the entire bedroom. This should make for better sleep, partly because the blue light emitted from your phone can delay your body’s release of melatonin, which helps your body go to sleep at night. But perking up after a bedtime Facebook “like” or getting anxious after reading a news story can also disrupt your ZZZs.So, put your phone a little further and who knows, you might even wake up and say good morning to your partner instead of checking your phone before you’re even out of bed. To foil that on iPhones and most recent Android phones, go to your phone’s settings and turn off the dots, known as badges, for all but the handful of apps you care most about. These might be messaging apps you use with friends, or news services you want breaking-news alerts from. But do you really need a red dot for the 2,346 unread emails you have?You can also turn off push notifications, app by app.With Facebook, you’ll need to go to the app’s own settings to turn off the dozens of notification categories, such as “updates on your friends since you last logged in.” Turning a category off will turn off dots for that category, too.
SHARE Published on February 12, 2019 The Odisha government has expressed interest in setting up a dedicated machine tool park in the Jajpur district of the State. The park is expected to come up at the Kalinga Nagar Industrial Complex covering at least 100 acres.A detailed proposal in this regard was submitted to the Union Heavy Industries and Public Enterprises Ministry late last month.If this materialises, it will be the second such machine tool park after Tumkur in Karnataka.The move comes after the Union Minister (for Heavy Industries and Public Enterprises), Anant Geete, during the “Capital Goods in Steel Sector: Manufacture in India” conclave, assured support to the State government for such a proposal.With 38-odd MoUs signed during the capital goods manufacturing conclave, around ₹39,400 crore worth of investments are expected in the sector.Downstream industriesAccording to Sanjeev Chopra, Principal Secretary, Industries Department, Government of Odisha, the (tool park) proposal is also in line with the State’s vision of promoting downstream industries in the metal sector.Chopra added that the process of developing dedicated parks like the National Investment and Manufacturing Zone (a steel cluster) in Kalinganar and an aluminium park at Angul have already been initiated. “The Odisha Industrial Infrastructure Development Corporation has recently submitted the proposal seeking its approval. This will enhance competitiveness of the Indian capital goods sector and promote downstream industries,” he told BusinessLine.Project detailsAccording to the detailed project report, the machine tools park is expected to have 58-odd units and will require an investment of ₹280 crore (approximately) towards infrastructure. Around 80 per cent of this cost will come in as grant from the Centre. The remaining 20 per cent and land needs will be fulfilled by the Odisha government.Another ₹500 crore of investment is expected to be made by the units that will set up shop there. The project will provide employment for 1,500 people.Focus will be on machine tools, tooling, dies and moulds; the heavy electrical equipment sector; the mining and construction equipment segment; the process plant equipment sector; and metallurgical machinery, including steel plant equipment. Other focus sectors would be plastics processing machinery and textile & jute machinery.“Land for the project has been identified and work is expected to start once clearances from the Ministry come through,” Chopra said. SHARE SHARE EMAIL skill development COMMENTS COMMENT